PD-0090: Altered fractionation radiotherapy for elderly patients with locally advanced head and neck cancer
نویسندگان
چکیده
منابع مشابه
palliative hypofractionated radiotherapy in locally advanced head and neck cancer with fixed neck nodes
background: the locally advanced head and neck cancer with fixed nodes are incurable and has a short survival. this study aims to evaluate the symptom relief, disease response and acute toxicity after palliative hypofractionated radiotherapy. methods: between december 2010 to june 2011, previously untreated 50 patients who had histopathologically proved of head and neck squamous cell carcinoma ...
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Results: In total, 40 patients were enrolled; median follow-up was 41 months. The majority of patients were clinical stage III (n=37, 92.5%), ≥ 50 year (n=34, 85%), and male gender (n=29, 72.5%). Approximately half of the patients had laryngeal cancer. The overall grade 3 acute toxicity was 62.5%; mainly mucositis (n=23, 57.5%) and dysphagia (n=18, 45%). Overall, 34 patients (85%) showed comple...
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Treatment of locally advanced head and neck cancer remains a challenge because of the head and neck complex anatomy and the tumor invasion to the adjacent organs and/or metastases to the cervical nodes. Postoperative irradiation or concurrent chemoradiation may lead to damage of radiosensitive structures such as the salivary glands, mandible, cochlea, larynx, and pharyngeal muscles. Xerostomia,...
متن کاملAltered fractionation for head and neck cancer.
A conventional course of radiation for squamous cell carcinoma in the United States is generally 70 Gy in 7 weeks, with a once-daily dose of 1.8 to 2 Gy. This schedule has a modest success rate in curing head and neck cancer. The past several decades have seen numerous investigations into altering this schedule to optimize the results of radiation. Two approaches, founded on radiobiologic princ...
متن کاملAltered Fractionation for Head and Neck Cancer
Delivery of therapeutic radiation in multiple sessions, or fractions, has been practiced since the discovery of radiation’s potential to cure malignancies. Initially, this was done out of practical necessity: Radiation was delivered at a low dose rate, and the treatment sessions had to be repeated to obtain the desired effect. Technologic improvements eventually allowed for treatments in one se...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2013
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(15)32396-3